Superman vs. Aliens? Sure, why not? He's been pitted against Luthor, Kryptonite, and the Supernatural so far in the digests...an aliens theme only makes sense.
Behind the funny, roustabout cover by Ross Andru and Dick Giordano, come these stories:
"The Legion of Super-Creatures" by Otto Binder, Curt Swan, and George Klein
"The Midget Menace" by Edmond Hamilton, Wayne Boring, and Stan Kaye
"The Thing From 40,000 A.D." by Bill Finger, Boring, and Kaye
"The Invulnerable Enemy" by Binder and Boring(sounds like a law firm)
"The Interplanetary Circus" by Robert Bernstein and Al Plastino
"Jimmy Olsen's Private Monster"(!) by Jerry Siegel, Swan, and Forte
"The Creature of 1,000 Disguises" by Hamilton, Boring, and Kaye
"The Super-Human Bomb" by Jim Shooter and Boring
"A Dog-House for Superman" by William Woolfolk and Plastino
...a pretty goofy collection, and I'm not sure why they stuck to the 50s-60s era so relentlessly instead of throwing in some newer tales, but what the hey.
I also enjoy Brainiac on the right of the cover, just sort of watching what's going on.