Aside from Archie Andrews, I guess you'd have to say Dennis the Menace was the digest format's biggest, longst-running star--Dennis the Menace Pocket Full of Fun was a completely separate digest-sized series that ran for fifty issues, each of them two-hundred pages thick! That's a lot of trouble for Mr. Wilson!
This particular issue features twenty different Dennis stories, all drawn by Hank Ketcham ghost artists who could ape his style perfectly. So while(like I said back when talking about the Marvel Dennis the Menace digest series)I still don't find the strip funny, the artwork is top-notch and a joy to look at.
Interesting note--this issue has one of those Statement of Ownership thingies. This digest series was selling over 140,000 copies each issue--take that, X-Men!